Spontaneous Tumour Lysis Syndrome Secondary to Metastatic Gallbladder Adenocarcinoma: a Case Report and Reflection

Abstract Tumour lysis syndrome (TLS) is a well-recognised oncological emergency caused by rapid destruction of cancer cells. Despite most commonly occurring in haematological malignancies or following initiation chemotherapy, rarely, it occurs solid tumours without any trigger. Release nucleic acids during cell breakdown produces large amounts uric acid resulting crystallisation within the renal tubules, clinically manifesting as severe acute kidney injury. We hereby discuss first reported case lethal spontaneous TLS 77-year-old patient admitted with newly diagnosed metastatic gallbladder adenocarcinoma and reflect on importance considering rarer causes AKI patients organ cancers.